T. Higuchi, K. A. Connors, “Phase Solubility Techniques,” Advanced Analytical Chemistry of Instrumentation, Vol. 4, 1965, pp. 117-212. has been cited by the following article: TITLE: Binary and Ternary Complexes of Arteether β-CD - Characterization, Molecular Modeling and in Vivo Studies [Article] - Phase Solubility Techniques I'm having a really hard time even finding a link to this article, but everyone cites it: Higuchi, T.; Connors, K. A., 1965. Adv.It was found that the solubility of ABPP increased linearly as a func- tion of BCD concentration and showed the fea- tures of an AL type (Higuchi and Connors, 1965). The apparent stability constant, K^.^, of the soluble complex at each temperature was calcu- lated according to the equation of Higuchi and Connors (1965), Eqn 1, where 5 is the …Phase solubility analysis The solubility measurements were performed according to the The phase solubility diagram of SMX and HP--CD, obtained by method of Higuchi and Connors [22] in aqueous solutions contain- plotting the changes in guest solubility as a function of HP--CD ing different concentrations of HP--CD, ranging from 14.3 mM ...Higuchi, KA Connors. Phase-solubility techniques. Adv Anal Chem Instrum 1965; 4: 117–212. Etodolak’ın Ko-kristalizasyonu: Ko-kristalizasyon Tahmini, Ko-kristal Sentezi, Katı Faz Yapı Aydınlatma Çalışmaları ve In Vitro İlaç Salımı ... Higuchi, KA Connors. Phase-solubility techniques. Adv Anal Chem Instrum 1965; 4: 117–212. Show All References …2 May 2011 ... It has to be noted that in the Higuchi and Connors method applied, Kc was obtained from the apparent cholesterol solubility, which comprises ...According to the Higuchi and Connors classification [6], the phase solubility diagram for the repaglinide – HP- β-CD inclusion complex is A type, which indicates the formation of a soluble complex.In this regard, the well-known solubility diagram design (T. Higuchi, K. A. Connors, “Phase Solubility Techniques,” Advanced Analytical Chemistry of Instrumentation, Vol. 4, 1965, pp. 117-212) should be done in order to obtain information about the drug solubility in presence of increasing CD concentrations.Phase solubility analysis The solubility measurements were performed according to the The phase solubility diagram of SMX and HP--CD, obtained by method of Higuchi and Connors [22] in aqueous solutions contain- plotting the changes in guest solubility as a function of HP--CD ing different concentrations of HP--CD, ranging from 14.3 mM ...There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience. After equilibrium was attained, the suspensions were filtered through 0.45 µm cellulose membrane filter, the filtrates diluted with the mobile phase and analyzed by HPLC. The apparent complexation constants for drug/cyclodextrin complexes (K 1:1) were determined according to the phase-solubility method of Higuchi and Connors.23 Ağu 2019 ... Figure 3: Higuchi-Connors diagram showing total substrate solubility versus CD concentration. A-type diagrams relate to the water-soluble ...Higuchi, T. and Connors, K. (1965) Phase solubility techniques, in Reilly, C. (ed.), Advances in Analytical Chemistry and Instrumentation, Wiley Interscience, New York, pp. 117–212. Google Scholar According to the phase-solubility diagram classification system that was introduced by Higuchi and Connors , linear A L-type diagrams show that the total drug solubility increases as a function of …It was found that the solubility of ABPP increased linearly as a func- tion of BCD concentration and showed the fea- tures of an AL type (Higuchi and Connors, 1965). The apparent stability constant, K^.^, of the soluble complex at each temperature was calcu- lated according to the equation of Higuchi and Connors (1965), Eqn 1, where 5 is the …Using the concept proposed by Higuchi and Connors , the solubility diagrams can be classified as the AL type. The observed increase of the drug solubility results from the formation of a drug-cyclodextrin inclusion complex with a stoichiometry of 1:1. ... Higuchi, T.; Connors, K.A. Phase solubility techniques. Adv. Anal. Chem. …It was found that the solubility of ABPP increased linearly as a func- tion of BCD concentration and showed the fea- tures of an AL type (Higuchi and Connors, 1965). The apparent stability constant, K^.^, of the soluble complex at each temperature was calcu- lated according to the equation of Higuchi and Connors (1965), Eqn 1, where 5 is the …Phase solubility profiles by Higuchi and Connors [45] Source publication. Mini Review on Synthesis and Characterization Methods for Ternary Inclusion Complexes of Cyclodextrins with Drugs....2.3. Solubility Measurements. Phase-solubility studies of benzoyl metronidazole in aqueous solutions of β-CD were carried out according to the Higuchi-Connors procedure . Various amounts of β-CD were generally dissolved in distilled water, and excess amounts of benzoyl metronidazole were loaded in glass vials. The vials were …AAPS PharmaSciTech 2005;6:464–72. 18. Higuchi T, Connors KA. Phase solubility techniques. Adv Anal Chem Instrum 1965;4:117–212. 19. Higuchi T, Kristiansen H. Binding specificity between small organic solutes in aqueous Solution, Classification of some solutes into two groups according to binding tendencies. J Pharm Sei 1970;59:1601–8. 20.7 Ağu 2017 ... All other reagents used are of analytical grade. Phase solubility study (Higuchi Connors method). Phase solubility studies were performed ...ResearchGate | Find and share researchAbstract. The interaction between ibuprofen and maltodextrins with different dextrose equivalent was studied in solution and solid state in order to investigate the effect on the solubility of ibuprofen and to determine their usefulness in terms of chiral recognition. Apparent binding constants were calculated using nuclear magnetic resonance ...13 Şub 2019 ... The phase solubility studies were carried out according to Higuchi and Connors. ... Phase-solubility techniques. Adv. Anal. Chem. Instrum. 4 ...The phase solubility diagram for Nag in SBE-β-CD system is shown in Fig. 1.The apparent solubility of Nag increased linearly as a function of SBE-β-CD concentration over the studied concentration range, which could be classified as A L type according to Higuchi & Connors. The slope value was less than one, indicating that the formation of …J Chem Educ 78(11): pharmaceuticals. Boca Raton, Florida: Taylor and Francis 1499. Group, LLC. Higuchi T, Connors KA (1965) Phase-solubility techniques. ACD/ChemSketch (2009) Version 12.01. Adv Anal Chem Instrum 4: 117–212.One of the most useful and widely applied analytical approaches in this context is the Phase–solubility method described by Higuchi and Connors [42].... Journal Article • DOI • Cyclodextrins in drug delivery: an updated review. 2 May 2011 ... It has to be noted that in the Higuchi and Connors method applied, Kc was obtained from the apparent cholesterol solubility, which comprises ...The K C and CE were calculated from the intrinsic solubility (S 0 ) in the complexing medium and the initial linear slope of the phase solubility diagram (Higuchi and Connors 1965;Loftsson et al ...also calculated whe re possible accordin g to Higuchi-Connors. 8 The methodolog y employed for . ... Connors KA. Phase Solubility Techniques. Advances in Analytical Chemistry and Instrumentation ...Phase solubility analysis. The phase solubility diagram for DEN and HPβCD obtained based on the methods of Higuchi and Connors 1965 (Fig. 3) can be categorised as AL-type. The solubility of DEN increases linearly with increase HPβCD concentration. The stability constant K was obtain from the linear portion in the phase …In this regard, the well-known solubility diagram design (T. Higuchi, K. A. Connors, “Phase Solubility Techniques,” Advanced Analytical Chemistry of Instrumentation, Vol. 4, 1965, pp. 117-212) should be done in order to obtain information about the drug solubility in presence of increasing CD concentrations.Higuchi T, Connors KA (1965) Phase-solubility techniques. Adv Anal Chem Instrum 4: 117 – 212. ICH Q6A Test procedures and acceptance criteria for newHiguchi T, Connors K. Phase-solubility techniques. Adv Anal Chem Instrum. 1965;7:117–212. Google Scholar Jouyban A. Handbook of solubility data for pharmaceuticals. Boca Raton: CRC Press; 2009. United States Pharmacopeial Convention. USP 38–NF 33, General notices and requirements.Solubility diagrams exhibit AL type according to the Higuchi and Connors classification [23], showing a linear increase ... Phase-solubility techniques. Adv Anal ...Higuchi, K.A. Connors, Phase solubility techniques Advances in Analytical Chemistry and Instrumentation 4: (1965) 127-212 4. F. Djedaïni, B. Perly, Nuclear Magnetic Resonance of cyclodextrin derivatives and inclusion compounds D. Duchene, New Trends in Cyclodextrins and Derivatives (1992) Editions de Santé Paris Ch. 6 5.Types of phase-solubility diagrams according to Higuchi and Connors showing how the total drug solubility changes with increasing CD concentration. A-type diagrams are formed when the drug/CD complex is soluble in the aqueous complexation media and they are usually associated with the water-soluble CD derivatives.According to the Higuchi and Connors classification [6], the phase solubility diagram for the repaglinide – HP- β-CD inclusion complex is A type, which indicates the formation of a soluble complex.May 11, 2018 · Types of phase-solubility diagrams according to Higuchi and Connors showing how the total drug solubility changes with increasing CD concentration. A-type diagrams are formed when the drug/CD complex is soluble in the aqueous complexation media and they are usually associated with the water-soluble CD derivatives. T. Higuchi, K. A. Connors, “Phase Solubility Techniques,” Advanced Analytical Chemistry of Instrumentation, Vol. 4, 1965, pp. 117-212. has been cited by the following article: TITLE: Binary and Ternary Complexes of Arteether β-CD - Characterization, Molecular Modeling and in Vivo StudiesThe phase solubility investigation was carried out according to Higuchi and Connors approach . Excess DoN was added to distilled water containing various concentrations of Kollidon VA 64 in 20-mL capped bottles, stirred for 48 h at 25 and °C on magnetic stirrer, filtered, and spectrophotometrically analyzed at 283 nm using a double …T. Higuchi and K. A. Connors. Phase solubility techniques. Adv. Anal. Chem. Instrum. 4:117-212 (1965). ... In S. Yalkowsky (ed.), Techniques of Solubilization of Drugs, Marcel Dekker, New York, 1981, pp. 135-149. Google Scholar T. Higuchi and H. Kristiansen. Binding specificity between small organic solutes in aqueous solution ...The two kinds of CDs enhance the aqueous solubility of Res. As shown in Fig. 2, the phase-solubility diagrams of Res with β-CD or HP-CD show a linear relationship between the amount of Res solubilised and the concentration of CDs in solution (A L type diagram). According to the theory of Higuchi and Connors (1965), this may be attributed …The mole fraction solubility of TDL was found to be highest in pure PEG 400 (1.86 × 10- 2 at 298.15 K) as compared to water (5.7 × 10- 7 at 298.15 K). The thermophysical parameters such as enthalpies and entropies for TDL dissolution indicated that the dissolution of TDL is endothermic and an entropy-driven process.According to the classification of the phase solubility diagram of Higuchi and Connors (Eq. 1), the HO-AAVPA solubility profiles correspond to the type A L phase diagrams, which support the ...24 Tem 2018 ... This phase-solubility technique was first developed by Higuchi and Connors. ... complex formation solubility, spectral and kinetic techniques. J ...The solubilization ability of CDs can be quantitatively evaluated by the phase solubility method developed by Higuchi and Connors . The phase solubility diagram at 25 °C was obtained by plotting the apparent equilibrium concentrations of the drug against βCD concentrations and is reported in Fig. 1. The apparent solubility of DMA increased ...Phase Solubility Studies. The determination of the phase solubility diagram is a widely accepted method for evaluation of the effect of cyclodextrin complexation on the drug solubility. The phase solubility studies were performed by the method reported by Higuchi and Connors . Increasing concentrations of MβCD (0–0.23 M) or …All the formulations were evaluated at pre and post compression level. Acid solubility profile showed higher solubility in HCl buffer pH2 (296.89±3.49 μg/mL). Mixture of propylene glycol and ...The phase solubility technique permits the evaluation of the affinity between HPβCD and raloxifene in water. Phase solubility studies were performed according to the method reported by Higuchi and Connors . As given in Table 1, raloxifene was taken into vials in an excess amount, and 20 ...One of the most useful and widely applied analytical approaches in this context is the Phase–solubility method described by Higuchi and Connors [42].... Journal Article • DOI • Cyclodextrins in drug delivery: an updated review. 2.3 Phase solubility studies. Phase solubility studies were carried out according to the method described by Higuchi and Connors (1965). 21 Excess amounts of EO were added to CD solutions at different concentrations ranging from 0 to 40mM. The mixtures were shaken overnight at 25°C and then filtered through a 0.45 μm membrane filter.T K Higuchi. T K Higuchi. Phase solubility techniques ... Phase solubility techniques. T K Higuchi. 1, A Connors. 1. View details (2 authors) Volume: 4, Pages: 212 - 217. …T K Higuchi. T K Higuchi. Phase solubility techniques ... Phase solubility techniques. T K Higuchi. 1, A Connors. 1. View details (2 authors) Volume: 4, Pages: 212 - 217. Published: Jan 1 ... Solubility. Phase diagram. Hildebrand solubility parameter. Paper Details. Title. Phase solubility techniques. Published Date. Jan 1, 1965. Volume. 4 ...Phase solubility study. Classification of inclusion complex formation and stability of the inclusion compounds were evaluated by phase solubility study (Higuchi & Connors, 1965). An excess of black pepper oil was added to 10 mL aqueous solutions of HPβCD ranging in concentration from 0 to 10 mmol/L and incubated at 25 and 35 °C for 24 h with ...Solubility studies. The phase-solubility diagrams were made according to the Higuchi and Connors method (Higuchi and Connors, 1969). For this purpose, aqueous solutions of HPβCD with concentrations of 0–2.6 mM with a known concentration of Los at 30 mM were prepared. These were placed in a thermostatic bath at 298 K by 48 h.The Higuchi and Connors 30 method was used to classify the phase-solubility profiles. The apparent stability constant ( K 1:1, eq 1 ) and the CE ( eq 2 ) were determined from the slope of the linear phase-solubility diagrams plots of the total drug solubility ([ D t ]) versus total concentration of CD in liquid phase ([CD liq ]) in moles per ...The phase solubility diagrams of DMY with α-CD, β-CD, γ-CD, HP-β-CD, and DM-β-CD obtained in water at 25 °C are shown in Fig. 1.The aqueous solubility of DMY increased linearly (r 2 ≥ 0.99) with increasing CD concentration at a range of 0–10 mM. All phase diagrams belonged to A L-type according to Higuchi and Connors, suggesting …Phase solubility analysis The solubility measurements were performed according to the The phase solubility diagram of SMX and HP--CD, obtained by method of Higuchi and Connors [22] in aqueous solutions contain- plotting the changes in guest solubility as a function of HP--CD ing different concentrations of HP--CD, ranging from 14.3 mM ...2.3 Phase solubility studies. Phase solubility studies were carried out according to the method described by Higuchi and Connors (1965). 21 Excess amounts of EO were added to CD solutions at different concentrations ranging from 0 to 40mM. The mixtures were shaken overnight at 25°C and then filtered through a 0.45 μm membrane …[16] T. Higuchi, K. A. Connors, “Phase Solubility Techniques”, Advances in Analytical Chemistry and Instrumentation, 4, 117-150, 1965. [17] T. Higuchi, H. Kristiansen, “Binding specificity between small organic solutes in aqueous solution: Classification of some solutes into two groups according to binding tendencies”, Journal …Stoichiometry and constant formation of the inclusion complex 1H 4 MGF:1βCD by Higuchi–Connors method. The method of Higuchi and Connors proposes that to determine the inclusion constant of a formed complex 1H 4 MGF:1βCD, the phase-solubility diagram, ([H 4 MGF] = f([βCD])) of saturated solutions in mangiferin must show a linear trend and then equation relates the slope (α) and intercept ...Phase solubility techniques. T K Higuchi, A Connors. 31 Dec 1964 - Vol. 4, pp 212-217. View 20 related papers. About: The article was published on 1965-01-01 and is currently …Jul 11, 2017 · Phase solubility study. The effect of complexation with βCD and HPβCD on the solubility of GA was assessed. The phase solubility diagram was used in order to evaluate the solubility of GA in the presence of CDs according to Higuchi & Connors . The amount of GA was kept in excess and mixed up with different concentrations of βCD (0–16 mM ... Phase solubility studies, according to the method of Higuchi and Connors [1] were used to evaluate the complexation in aqueous solution at room temperature. In the present study inclusion complexes of retinol with E-CD and with O-CD were prepared to prevent its rapid degradation.Solubility method (phase solubility analysis) Solubility studies were carried out according to the method reported by Higuchi and Connors (1965) . Excess amounts of DAN were added to aqueous solutions (pH 6.2 ± 0.1) containing increasing concentrations of BCD (2.0 × 10 −3 to 14.0 × 10 −2 M) and the samples were shaken on …The phase solubility diagrams for curcumin/cyclodextrin polymer inclusion complex is shown in Figure 5, which displayed an AL-type according to Higuchi and Connors . According to Higuchi and Connors’ theory, the 1:1 stoichiometry of the inclusion complex was achieved from the initial ascending part of the curve, a nearly …Phase solubility studies of BDQ in the presence of SBE-β-CD was performed according to the method described by Higuchi and Connors [30] and previously ...The phase solubility analysis described by Higuchi and Connors is the most widely used method to describe inclusion complexation (Brewster and Loftsson 2007; Challa et al. 2005). The excess insoluble drug is placed in vials with a constant volume of aqueous carrier containing several solutions with high concentrations of CD.Phase solubility analysis. The phase solubility diagram for DEN and HPβCD obtained based on the methods of Higuchi and Connors 1965 (Fig. 3) can be categorised as AL-type. The solubility of DEN increases linearly with increase HPβCD concentration. The stability constant K was obtain from the linear portion in the phase solubility diagram ...also calculated whe re possible accordin g to Higuchi-Connors. 8 The methodolog y employed for . ... Connors KA. Phase Solubility Techniques. Advances in Analytical Chemistry and Instrumentation ...5. Higuchi T, Connors K. Phase-solubility techniques. Advances in Analytical Chemistry and Instrumentation, 4, 1965, 117-212 6. Renu Chadha, Anupam Saini, Poonam Arora, Somnath Chanda. Co-crystals of efavirenz with selected coformers: preparation and characterization. International Journal of Pharmacy and Pharmaceutical Sciences Vol 4, …Then K 1:1 is calculated from the slope and S 0 according to Higuchi and Connors : ... obtained from phase-solubility diagrams are most frequently observed constants that are composed of a number of true stability constants for multiple types of ... Higuchi, T., Connors, A.K.: Phase-solubility techniques. Adv. Anal. Chem. Instrum. 4, …This article reports the solubilization of the practically water insoluble drug molecules such as nifedipine, niclosamide and furosemide by guest:host inclusion complexation with p-phosphonates calix[n]arenes as drug soluble agent. This complexation studies were carried out by using the phase solubility technique. From the obtained …The influence of both temperature and CYD concentration on complex solubility was studied using the method of Higuchi and Connors (Adv. Anal. Chem., 4 (1965) 117–212). This is based on monitoring changes in the solubility of substrate (salbutamol) on the addition of complexing agents (α-, β-, Me-β- and γ-CYD).The phase solubility technique permits the evaluation of the affinity between HPβCD and raloxifene in water. Phase solubility studies were performed according to the method reported by Higuchi and Connors . As given in Table 1, raloxifene was taken into vials in an excess amount, and 20 ...Higuchi, K.A. Connors, Phase solubility techniques Advances in Analytical Chemistry and Instrumentation 4: (1965) 127-212 4. F. Djedaïni, B. Perly, Nuclear Magnetic Resonance of cyclodextrin derivatives and inclusion compounds D. Duchene, New Trends in Cyclodextrins and Derivatives (1992) Editions de Santé Paris Ch. 6 5.Phase-solubility studies. Solubility measurements were performed in triplicate using the method reported by Higuchi and Connors [13]. An excess amount of CAR was added to the aqueous solutions of Soluplus® in water containing increasing concentrations of Soluplus® (0–20% w/v).Phase solubility techniques. T K Higuchi, A Connors. 31 Dec 1964 - Vol. 4, pp 212-217. About: The article was published on 1965-01-01 and is currently open access. It has received 2363 citation (s) till now. The article focuses on the topic (s): Phase (matter) & Solubility. It was found that the solubility of ABPP increased linearly as a func- tion of BCD concentration and showed the fea- tures of an AL type (Higuchi and Connors, 1965). The apparent stability constant, K^.^, of the soluble complex at each temperature was calcu- lated according to the equation of Higuchi and Connors (1965), Eqn 1, where 5 is the …PHASE SOLUBILITY TECHNIQUE IN STUDYING THE FORMATION OF COMPLEX SALTS OF TRIAMTERENE J Pharm Sci. 1964 Nov;53:1325-8. doi: 10.1002/jps.2600531108. Authors L W DITTERT, T HIGUCHI, D R REESE. PMID: 14253586 DOI: 10.1002/jps.2600531108 No abstract available. MeSH terms Chemistry, Pharmaceutical* ...Phase solubility test Phase solubility studies were performed according to the methods described by Higuchi and Connors ( Higuchi & Connors, 1965 ). Excess amounts of quinestrol was suspended in a 0.1 mol/L phosphate buffer solution (pH 7.0) containing increasing amounts of DM-β-CD (from 0 mM to 10.00 mM).Solubility studies. The phase-solubility diagram corresponding to DPS:βCD system is illustrated in Fig. 5. It was performed according to the method reported by of Higuchi and Connors in order to determine the stability constant of the suggested complex and evaluate its stoichiometry. Measurements were made at 291 nm, which …Types of phase-solubility diagrams according to Higuchi and Connors showing how the total drug solubility changes with increasing CD concentration. A-type diagrams are formed when the drug/CD complex is soluble in the aqueous complexation media and they are usually associated with the water-soluble CD derivatives.Solubility diagrams were obtained according to Higuchi and Connors (1965). Excess amounts of sulfamethizole were added to water containing various concentrations of cyclodextrins and the suspensions were shaken at 37°C. ... Phase solubility techniques. Adv. Anal. Chem. Instr., 4 (1965), pp. 117-212. View in Scopus Google Scholar. Job, …The phase solubility results indicated the formation of a IDE/SBE-β-CD inclusion complex with 1:1 molar ratio (A L type diagram), whose apparent stability constants at T = 300, 310, and 320 K have been estimated according to the Higuchi–Connors method. The formation of the inclusion complex has been confirmed on a freeze-dried …Higuchi and Connors, "Phase-Solubility Techniques,", 1964, Box: 1, Phase solubility studies. Degree of complexation between nanosponges and , Phase solubility study. The stoichiometry and the overall complex formation constant K 3 were measured a, There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen t, T. Higuchi, K. A. Connors, “Phase Solubility Techniques,” Adv, Higuchi T, Connors K. Phase-solubility techniques. Adv Anal Chem Instrum. 1965;7:117–212. Google S, The phase solubility study was carried by the Higuchi an, All solubility measurements were performed six times. 2., Higuchi and Connors, "Phase-Solubility Techniques,", 1964,, also calculated whe re possible accordin g to Higuchi-Co, The phase solubility curve was a typical AL-type c, The complexation of diosmin with βCD and HPβCD both i, According to the classification method of Higuchi and, Methods: Phase solubility studies revealed Bs type plo, Solubility diagrams were obtained according to Higuc, Phase solubility analysis. The phase solubility diagram fo, All the formulations were evaluated at pre and post comp, Shake flask method was employed for the aqueous solubili.